Most center-fire big game rifles actually vary little in the amount of bullet drop from 100 to 400 yards - which will accomodate the needs of easily 80- to 90-percent of all deer, elk, antelope, black bear, caribou, moose, mountain goat, wild sheep, or any other kind of big game hunter. Quite honestly, just 10- to 20-percent of big game hunters will ever attempt shots out to 500 yards and farther.
In reality, the vast majority of big game shot in the United States is shot well inside of 200 yards. And just about any rifle, chambered for cartridges ranging from the .243 Winchester & 6mm Remington...all the way up to the .300 Winchester Magnum, or the .338 Winchester Magnum for that matter, can be sighted to impact 1.5 to 2.5 inches high at 100 yards...and will put the bullet so close to on at 200 yards that even the hunter who pulled the trigger won't be able to tell is the shot went an inch or so this way or that way.
There is no bullseye on a white-tailed deer...pronghorn antelope...or bull elk. In fact, the idea is to hold center of a "kill area" that, on deer-sized game, is pushing 10 inches in diameter - like the area covered by the white circle seen on the buck above. And using the standard corsshair, sighted as just mentioned, most any center-fire rifle will put that bullet well inside of the kill zone.
If Hi-Lux were to develop a PHS scope (Practical Hunter Series), using the same concept as the short-bar reticles used in the HPML scope, the long list of calibers and loads below would all place the bullet inside the faint oval outlined by the series of dots - using the first cross bar at 300 yards...and using the lower crossbar at 400 yards would keep any of the following cartridges and loads inside the white kill zone.
.243 Winchester
Federal 70 gr. +1.1" 0 -5.9" -18.0"
Federal 90 gr. +1.4" 0 -6.1" -19.2"
Federal 100 gr. +1.6" 0 -7.5" -22.0"
(6mm Remington is basically the same )
.25-06 Remington
Federal 115 gr. +1.6" 0 -7.2" -21.4"
Remington 120 gr. +1.6" 0 -7.2" -21.4"
.270 Winchester
Federal 130 gr. +1.5" 0 -6.7" -19.8"
Hornady 150 gr. +1.7" 0 -7.4" -21.6"
Winchester 150 gr. +1.7" 0 -7.4" -21.6"
7mm-08 Remington
Federal 140 gr. +1.7" 0 -7.9" -23.2"
Winchester 140 gr. +1.9" 0 -8.0" -23.8"
.280 Remington
Remington 140 gr. +1.5" 0 -7.0" -20.5"
Speer 160 gr. +1.7" 0 -7.7" -22.4"
7mm Remington Magnum
Federal 140 gr. +1.4" 0 -6.7" -19.9"
Federal 160 gr. +1.7" 0 -7.9" -23.3"
Federal 175 gr. +1.8" 0 -8.2" -24.0"
Winchester 160 gr. +1.6" 0 -6.9" -20.1"
.308 Winchester
Federal 150 gr. +2.0" 0 -8.8" -26.3"
Federal 180 gr. +2.2" 0 -9.2" -28.2"
Remington 150 gr. +2" 0 -8.8" -26.2"
Remngton 180 gr. +2.3" 0 -9.7" -28.3"
.30-06 Springfield
Federal 150 gr. +1.8" 0 -8.2" -24.4"
Federal 180 gr. +2.1" 0 -9.0" -26.4"
Winchester 150 gr. +2.1" 0 -8.5" -25.0"
Winchester 180 gr. +2.4" 0 -9.3" -27.0"
.300 Winchester Magnum
Federal 180 gr. +1.6" 0 -7.4" -21.9"
Federal 200 gr. +1.9" 0 -8.2" -23.9"
Remington 180 gr. +1.6" 0 -7.2" -20.8"
Winchester 180 gr. +1.6" 0 -7.1" -20.7"
.300 Winchester Short Magnum
Federal 180 gr. +2.2 0 -9.9" -21.4"
Winchester 150 gr. +1.3" 0 -6.6" -19.6"
.308 Marlin Express
Hornady 160 gr. +2.8" +1.6" -6.8" -23.6"
.338 Winchester Magnum
Federal 225 gr. +1.9" 0 -8.4" -24.5"
Winchester 200 gr. +1.6" 0 -7.1" -20.8"
.35 Whelen
Federal 225 gr. +2.3" 0 -9.4" -27.3"
The range of bullet drop for all of these popular cartridges, with a 200 yard zero, at 300 yards is from 5.9" to 9.9" - and the range of bullet drop at 400 yards is from 18.0" to 28.3".
A good 2.5-10x44mm scope, with a primary crosshair...and a short bar reticle set for 300 yards ...and another set for 400 yards... could prove to be one very popular scope, allowing a very large percentage of today's big game hunters to sight in "dead on" at 200 yards, and with the proper reticle...hold "dead on" their target out to 400 yards and take, and make, the shot. And it's all done without mechanics or electronics.
There are easily 7 or 8 other big game caliber rifles that could also be included on the above list - plus several smaller calibers. One is the .223 Remington (or 5.56mm). Sighted on at 200 yards, the 55 grain Federal round would be +1.6" @ 100 yards...-8.2" @ 300 yards...and -26.1" at 400 yards (not much different than the 150-grain .308 round).
There's a difference between precision target shooting and practical hunting shot placement.